贵阳城区成人维生素D营养状况调查

Vitamin D status in healthy adults in Guiyang of China

目的调查贵阳城区成人维生素D营养状况。方法用整群抽样的方法抽取贵阳市云岩区宅吉社区中20～79岁（年龄中位数为45．2岁）健康成人1500名，于2009年11月至2010年2月进行问卷调查，并采集清晨空腹静脉血分离血清，用美国DiaSorin公司的放射免疫试剂盒测定血清25．羟维生素D[25（OH）D]水平。结果贵阳城区成人血清25（OH）D平均水平为（20．4±9．0）ng/ml；成人25（OH）D缺乏[25（OH）D〈20ng／ml]、不足[20ng／ml≤25（OH）D〈30ng/ml]、正常[25（OH）D≥30ng／ml]分别为52．3％、32．3％及15．4％。贵阳城区青年、中年、老年人群血清25（OH）D平均水平依次为（18．2±9．2）、（22．8±8．7）及（19．9±7．8）ng／ml。青年、中年与老年人群维生素D缺乏依次为62．8％、40．2％与55．4％。高学历人群（≥13年）维生素D缺乏为61．6％，低体重人群（体重指数〈18．5kg／m^2）维生素D缺乏为64．4％。结论贵阳城区成人维生素D缺乏普遍，尤其见于老年人及青年人群，并受文化程度、年龄、吸烟等因素影响。

Objective To evaluate vitamin D status in healthy adults living in Guiyang. Method 1 500 healthy volunteers aged 20-79 years （ mean 45.2 years） were recruited from a community in Guiyang by cluster sampling method. Questionnaires for living habits and fasting blood samples were collected from November, 2009 to February, 2010. Serum 25 （OH）D concentrations were measured by radioimmunoassay, using the DiaSorin kit, USA. Results The average serum 25 （OH） D level was （20. 4 ±9.0 ） ng/ml. The percentages of vitamin D deficiency [ 25 （ OH ） D 〈 20 ng/ml ], insufficiency [ 20 ng/ml ≤25 （ OH ） D 〈 30 ng/ml ], and sufficiency [ 25 （ OH ） D I〉 30 ng/ml ] were 52. 3 % , 32.3 % , and 15.4 % , respectively. The 25 （OH） D concentrations in the young, middle-aged, and elderly were （ 18. 2±9. 2）, （22. 8±8. 7）, and （ 19. 9±7. 8 ） ng/ml, respectively. The percentages of vitamin D deficiency in these groups were 62. 8%, 40. 2%, and 55.4%, being 61.6% in higher educational group （ ≥ 13 years） and 64. 4% in the group with lower body mass index （ 〈 18. 5 kg/m^2 ）. Conclusion Vitamin D deficiency is common in Guiyang including all age groups, especially among the youth and the elderly. Serum 25-hydroxyvitamin D level is also influenced by education, age, smoking, and other factors.