头孢美唑的血、尿、病灶浓度测定及其人体内药动学研究

Determination of Cefmetazole Concentration in Blood,Urine and Target Focus and Pharmacokinetics Study of It

目的:测定头孢美唑的血、尿、病灶浓度,分析体内药动学规律,为临床合理用药提供依据。方法:选择住院患者75例,其中呼吸系统疾病患者40例,外科手术患者35例,采用微生物法测定血药、尿药浓度,其中外科手术患者35例同时平行测定病灶浓度。结果:静脉滴注头孢美唑的体内动态规律,符合开放二室模型;清除率(CL)与肌酐清除率(Ccr)呈线性相关;病灶浓度较血药浓度平行后移2～3h并高于血药浓度的6～7倍,感染性病灶药物浓度高于非感染性病灶,具有显著性差异(P<0.05)。结论:头孢美唑分布较好,是外科感染的有效药物。头孢美唑在体内以原型从尿中排出,肾功能对其排泄有一定影响。

OBJECTIVE： To determine cefmetazole （CMZ） concentration in the blood, urine and target focus and analyze pharmacokinetic regularity, and to provide reference for rational drug use in the clinic. METHODS： 75 inpatients were selected, including 40 patients with respiratory disease and 35 surgery patients. CMZ concentration in the blood and urine were determined by mi- croorganism method and CMZ concentration in target focus of 35 surgery patients were also determined. RESULTS： Dynamic rule of intravenous infusion of cefmetazole conformed to the opening two-compartment model, and clearance （CL） and creatinine clearance rate （Ccr） were linearly related. CMZ levels in the target focus parallelled backward-shift within 2-3 h and wrer higher 6-7 times than those in the blood. CMZ concentrations in infective target focus were higher than those in non-infective target focus, there was a significant difference （P〈0.05）. CONCLUSION： Because CMZ may better distribute to the target focus from the blood, it is also an effective medicine for surgical infection. CMZ is cleansed as prototype from the urine without metabolism in vivo, renal function has some influence on its excretion.