丙戊酸镁缓释片治疗症状性癫痫97例临床分析

Clinical Analysis of Magnesium Valprote Sustained-release Tablets in the Treatment of 97 Cases of Symptomatic Epilepsy

目的:了解传统药丙戊酸镁缓释片对症状性癫痫的疗效。方法:以患者用药前4周内癫痫发作次数为基线,之后单用丙戊酸镁缓释片治疗,随访6个月～3年。以用药后每4周的发作次数与用药前基线比较,临床发作减少49%及以下者为无效,减少50%～99%为有效,临床无发作为控制。结果:在对97例症状性癫痫的研究中发现,丙戊酸镁缓释片治疗由于头外伤引起癫痫的发作控制率为64.7%;脑血管病所致癫痫的发作控制率为73.3%;脑肿瘤所致癫痫的发作控制率为57.1%;脑囊虫所致癫痫的发作控制率为54.5%。总有效率82.5%。结论:丙戊酸镁缓释片对症状性癫痫具有较好的疗效,其中对脑血管病、头外伤、肿瘤、脑囊虫等所致的癫痫可能具有更大的优势。

OBJECTIVE： To explore the therapeutic effect of traditional medicine Magnesium valprote sustained-release tablets in the treatment of symptomatic epilepsy. METHODS： The number of epilepsy attack in 4 weeks before medication was used as baseline and recorded, then Magnesium valprote sustained-release tablets therapy was given to 97 patients and followed up 6 months-3 years. The number of epilepsy attack in 4 weeks after medication was compared with baseline. The average seizure frequency reduced by below 49% was ineffective while by 50%-99% was effective. No epilepsy attack was considered as well-controlled. RESULTS： The study of 97 patients with symptomatic epilepsy showed that the control rate of Magnesium valprote sustained-release tablets against head trauma-induced epilepsy was 64.7% ; against cerebrovascular disease-induced epilepsy was 73.3%; against cerebral tumor-induced epilepsy was 57.1%; against cerebral cysticercosis was 54.5%. The total effective rate was 82.5%. CONCLUSION： Magnesium valprote sustained-release tablets are effective in the treatment of symptomatic epilepsy, especially symptomatic epilepsy caused by cerebrovascular disease, head trauma, tumor and cerebral cysticercosis.