荷电中空纤维膜对肝素钠的分离特性

Separation property of heparin by the charged hollow fiber membrane

在紫外辐照下,引发聚砜(PSF)中空纤维膜与2-丙烯酰胺-2-甲基丙磺酸(AMPS)的表面化学接枝反应,制备得到荷负电型PSF-g-AMPS膜,研究了该荷电膜对肝素钠的分离浓缩特性。实验结果表明,紫外光引发膜接枝过程中辐照时间、接枝单体浓度、肝素钠溶液的pH值影响着膜的渗透通量及截留效果。在辐照时间为2 min、AMPS单体浓度为1%条件下得到的荷电膜在0.1MPa压力下对肝素钠具有最佳的截留效果。溶液pH=9的条件下,膜对肝素钠具有较高的截留率,而在pH=5条件下具有较高的渗透通量。荷负电膜与带阴离子基团肝素钠的静电排斥效应使得膜对肝素钠的截留率提高,而接枝链的亲水性使得膜的渗透通量得以提高。

The negative charged hollow fiber membrane was prepared by ultraviolet irradiation induced 2-acrylamide-2-methyl-propanesulfonic acid（AMPS）grafting polymerization on the surface of PSF membrane.In this paper,the separation of heparin sodium by the charged membrane was investigated.Experiment results indicated that irradiation time,monomer concentration and pH value of heparin sodium solution affected the membrane separation performance.When irradiation time was 2 min,AMPS monomer concentration was 1%,operation pressure was 0.1 MPa,charged membrane had high retention performance and maximum permeate flux of heparin sodium solution.The retention rate of charged membrane to heparin sodium was higher at pH value of 9.The permeate flux of membrane was higher at pH value of 5.The effect of electrostatic repulsion among charged membrane and anionic heparin sodium caused higher permeate flux and retention performance.