滋肾养精法在多囊卵巢综合征肾虚证腹腔镜术后的应用研究

Application of Therapy of Nourishing Kidney Essence in Polycystic Ovary Syndrome Patients with Kidney Deficiency After Laparoscopic Surgery

目的:观察滋肾养精法中药在多囊卵巢综合征(polycystic ovary syndrome,PCOS)肾虚证患者腹腔镜术后应用的临床疗效。方法:将53例肾虚证PCOS患者随机分为治疗组30例、对照组23例,治疗组在腹腔镜术后加用滋肾养精法中药治疗,对照组不加用药物治疗。观察促卵泡生成素(FSH)、促黄体生成素(LH)、睾酮(T)测定结果,并随访妊娠结果。结果:治疗组病情疗效治愈率为53.33%,总有效率为93.33%,对照组分别为26.09%和73.91%,2组治愈率比较,差异有显著性意义(P<0.05),总有效率比较,差异无显著性意义(P>0.05)。治疗组中医证候疗效总有效率为90.00%,对照组为43.48%,2组比较,差异有显著性意义(P<0.05)。术后3月,2组T、LH/FSH与分别治疗前比较,差异有非常显著性意义(P<0.01);术后6月,对照组T、LH/FSH分别与术后3月比较,差异有显著性意义(P<0.05)。治疗组妊娠率为46.67%,对照组为21.74%,2组比较,差异有显著性意义(P<0.05)。结论:肾虚证PCOS腹腔镜术后患者配合应用滋肾养精法中药确实有效。

Objective.. To observe the effect of therapy of nourishing kidney essence on patients of polycystic ovary syndrome（PCOS）with kidney deficiency after laparoscopic surgery. Methods： Fifty-three cases of PCOS with kidney deficiency were divided into the treatment group （n=30）and the control group（n=23）. The treatment group received the decoction of Chinese herbal medicine with the actions of nourishing kidney essence after laparoscopic surgery. The control group had no medication after laparoscopic surgery. The serum levels of follicle-stimulating hormone（FSH）, luteinizing hormone（LH）and testosterone（T） were detected. The pregnancy rate was evaluated during the follow-up. Results： The cure rate and the total effective rate in the treatment group were 53.33% and 90.00% respectively, and were 26.09% and 73.91% respectively in the control group. The difference of cure rate between the two group was significant（P 〈 0.05）, but that of the total effective rate was insignificant （P 〉 0.05）. The total effective rate of TCM symptoms and signs in the treatment group was 90.00%, and was 43.48% in the control group, the difference being significant （P 〈 O.05）.The differences of serum T level and LH/FSH ratio were significant in both groups three months after surgery compared with those before surgery（P 〈 0.01）. Serum T level and LH/FSH ratio in the control group six months after surgery differed from those three months after surgery（P 〈 0.05）.The pregnancy rate was 46.67% in the treatment group and was 21.74% in the control group, the difference being significant （P 〈 0.05）. Conclusion. Therapy of nourishing kidney essence after laparoscopicsurgery has certain effect on patients of PCOS with Kidney deficiency.