布托啡诺联合氟比洛芬酯用于鼻内窥镜手术的临床观察

Analgesic effect of butorphanol combined with flurbiprofen axetil in patients after operation of nasal endoscope

目的:研究布托啡诺联合氟比洛芬酯用于鼻内窥镜手术镇痛的作用效果。方法:90例患者分为3组,每组30例,A组术前10 min静注氟比洛芬酯1 mg.kg-1,手术结束前10 min静注布托啡诺1.5 mg;B组术前10 min静注氟比洛芬酯1 mg.kg-1,手术结束前10 min静注曲马多1 mg.kg-1;C组术前10 min静注氟比洛芬酯1 mg.kg-1,手术结束前10 min静注生理盐水10 mL。观察并记录术毕给药后1,2,4,8 h的视觉模拟评分(VAS评分)及不良反应。结果:A组与B组VAS评分在术后8 h内各时点均无显著差异(P>0.05),但均低于C组,差异有显著性(P<0.05);不良反应方面,B组显著高于其他两组,差异有显著性(P<0.05),而A组与C组无显著差异(P>0.05)。结论:联合氟比洛芬酯超前镇痛作用,布托啡诺与曲马多有相似的镇痛效果,但不良反应少,是鼻内窥镜手术患者术后镇痛的良好选择。

Objective：To observe the analgesic effect of butorphanol combined with flurbiprofen axetil in patients after the operation of nasal endoscope.Methods：Ninety patients were randomly divided into 3 groups.At 10min before the operation,patients received intravenous flurbiprofen 1mg·kg-1 in all patients.At 10min before the end of the operation,the patients received butorphanol 1.5mg,tramadol 1mg·kg-1 or saline 10mL intravenously.The visual analogue scale（VSA） and side effects were observed 1,2,4 and 8h after the operation.Results：The VSA scores of patients in butorphanol and tramadol groups were lower than saline group at each time point（P0.05）.The side effects in tramadol group were more than butorphanol and saline groups（P0.05）.Conclusion：Butorphanol has the same analgesic effect as tramadol in combination with flurbiprofen axetil,but has fewer side effects.This analgesic method is a beneficial choice in the nasal endoscope operation.