1例肺脓肿患者抗感染治疗引发红皮病型药疹的病例讨论

A case of antibiotics-induced erythroderma in a patient with lung abscess

文章是关于临床药师参与救治的个案。1例50岁的男性患者,因肺脓肿接受万古霉素和美罗培南治疗,患者在病情好转后出院治疗,出现了疑似青霉素过敏导致的红皮病型药疹。再次入院后,针对患者的肺脓肿和红皮病,药师与临床医师密切配合,重新调整抗感染治疗方案,并加用糖皮质激素等治疗红皮病。观察治疗反应和病情变化,积极提供药物信息或循证证据,辅助临床合理选择药物,及时调整治疗方案,最终获得良好疗效。

A 50-year-old male patient underwent vancomycin and meropenem treatment.Clinical pharmacists closely participated to the treatment of his lung abscess.The patient developed to suspected penicillin-induced erythrodema during his outpatient-antibiotic treatment including penicillin.After readmitting his antibiotics regimen was changed for the sake of his allergy,while glucocorticoid was added to treat the erythroderma.Pharmacists cooperated with the clinical staff to monitor the treatment reactions and changes in patient＇s condition,to provide drug information or evidence in rationally choicing drugs,and finally to adjust the therapeutic regimen for beneficial effects.