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细胞间隙连接异常与肿瘤 被引量：1

Aberrant gap junction and tumor
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摘要 间隙连接是相邻细胞间进行物质和信息交换的跨膜蛋白通道结构，是细胞间隙连接通讯的结构基础。间隙连接在多种肿瘤中常发生异常改变，与肿瘤的发生、转移等密切相关。将间隙连接作为靶点设计抗癌新药物，将为肿瘤治疗提供新方向。 Gap junctions are membrane structures made of intercellular channels that allow directly exchange of material and information between adjacent ceils. It is the structural basis of gap junctional intercellular communication. Gap junction is aberrant frequently in variety of cancers, which relatives with tumor genesis and metastasis. New anti-cancer drugs targeting gap junctions will be a new direction for tumor treatment.
作者 王娟 夏娟
机构地区 中山大学光华口腔医学院黏膜科
出处 《国际肿瘤学杂志》 CAS 2011年第8期582-585,共4页 Journal of International Oncology
基金 国家自然科学基金资助项目（30600710）
关键词 连接蛋白类 缝隙结合部 肿瘤 细胞间通讯 Connexins Gap junction Neoplasms Cell communication
分类号 R730.2 [医药卫生—肿瘤]
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参考文献28

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同被引文献19

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国际肿瘤学杂志
2011年 第8期

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