galetin-3和EGFR蛋白在食管鳞状细胞癌中的表达及临床意义

Expression and clinical significance of galetin-3 and EGFR proteins in esophageal squamous carcinoma

目的探讨食管鳞状细胞癌（ESC）组织中半乳糖凝集素-3（Gal-3）和表皮生长因子受体（EGFR）蛋白表达与ESC生物学行为的关系。方法应用免疫组织化学方法，检测80例ESC组织中Gal-3和EGFR蛋白表达水平。结果Gal-3和EGFR表达阳性率分别为73．8％（59／80）和56．3％（45／80），二者在分化程度低、浸润程度深及发生淋巴结转移的EsC组织中的表达均显著高于分化程度高、浸润程度浅及未发生淋巴结转移的ESC组织（P〈0．05）；Gal-3和EGFR蛋白高表达的ESC患者死亡率高，生存率低（P〈0．05）。结论Gal-3和EGFR异常表达与ESC的病理生物学行为密切相关，可作为预测ESC转移潜能和评估EsC患者预后的客观指标。

Objective To explore the correlation of expression of galetin-3 （Gal-3） and epidermal growth factor receptor （EGFR） with the biological behaviors in esophageal squamous carcinoma（ESC）. Meth-, ods Immunohistochemical method was used to examine the expression of Gal-3 and EGFR in 80 specimens of ESC. Results The positive rates of Gal-3 and EGFR was 73.8% （59/80）and 56.3% （45/80） respectively. The positive rates of Gal-3 and EGFR expression in the patients with poor differentiation, deep infiltration and lymph node metastasis was significantly higher than those with well differentiation, shallow infiltration and without lymph node metastasis （ P 〈 0.05）. The high expression of Gal-3 and EGFR was correlated with higher percentage of death and lower survival rate （P 〈 0.05）. Conclusion The abnormal expression of Gal-3 and EGFR is closely related with the pathological biology behaviors of ESC. Gal-3 and EGFR can be regarded as objective indicators for forecasting metastasic potential of ESC and estimating prognosis of patients with ESC.