218例40岁以下青年人肺癌临床特征分析

Ciinico-pothologic studies on 218 lung cancer patients under 40 years of age

目的探讨≤40岁青年人肺癌的临床及病理特征，并与〉40岁的中老年人肺癌进行比较。方法对218例青年人肺癌（青年组）以及同期的944例中老年人肺癌（中老年组）进行回顾性分析，比较两组临床及病理特征。结果青年组女性患者比例高（39％vs27％，P〈0．001），以腺癌为主要病理类型（50．9％），病理类型构成与中老年组相比有显著差异（P〈0．001）。咳嗽是最常见的症状（73．9％），其他症状的发生率均不高。青年组患者确诊时晚期比例高（76．0％vs48．0％，P〈0．001），接受手术治疗比例显著低于中老年组（P〈0．001），接受综合治疗比例也较低（20．2％）。结论青年人肺癌具有其特殊的临床及病理特征，明显不同于中老年人肺癌，应提高对青年人肺癌的认识。

Objective To study whether the clinico-pothologic characteristics of young lung cancer patients （≤40 years of age） and compare with those of older lung cancer patients （〉40 years of age）. Methods Retrospective analysis was carried out to compare the clinico-pathologic features of 218 young patients （young group） with those of 944 older ones （older group）. Results Compared with the older group,young group had more female （39% vs 27%, P 〈0. 001）, different constitution of pathological types （P 〈0.001） characterized with more adenocarcinoma （50.9%）, more advanced stage disease （76.0%vs48.0%, P〈0.001） and less patients underwent surgery （P〈0.001）. Cough was the most common presentation （73.9%）,and other symptoms were not common. Combined-modality therapy was not common （20.2%） in the young group. Conclusions Young patients with lung cancer present difference in clinieo-pathologic features from the older ones. The younger type of lung cancer should be paid attention to.