摘要
目的研究阿托伐他汀联合氯吡格雷对急性冠脉综合征患者的颈动脉内膜-中层厚度(IMT)、血脂和超敏C反应蛋白(hs-CRP)水平的影响。方法将71例合并颈动脉硬化的急性冠脉综合征患者随机分为两组:对照组34例,在常规药物治疗的基础上,给予氯吡格雷治疗;试验组37例,在对照组治疗的基础上给予阿托伐他汀治疗。总疗程20周。比较两组患者治疗前、后的颈动脉IMT、TG、TC、LDL-C、HDL-C、LP(a)和hs-CRP的变化。结果治疗20周后,两组IMT较治疗前均有降低(P<0.05),而试验组IMT较对照组降低更明显(P<0.05)。试验组中TG、TC、LDL-C、LP(a)和hs-CRP明显下降,而HDL-C显著增高,与治疗前及对照组比较,差异均有统计学意义(P<0.05)。结论阿托伐汀联合氯吡格雷可以有效调脂、减轻炎症反应,能有效延缓动脉硬化的进展。
Objective To investigate the effect of atorvastatin combined with clopidogrel on carotid artery intima-media thickness（IMT）,plasma levels of lipids and high sensitive C-reaction protein（hs-CRP） in patients with acute coronary syndrome.Methods 71 patients were divided into control group（n=34） and experimental group（n=37）.Patients in the control group were given clopidogrel besides routine treatment.Patients in the experimental group were given atorvastatin on the basic treatment of control group.The total treatment course was 20 weeks.The IMT of carotid artery,1evels of TC,TG,LDL-C,HDL-C,LP（a） and hs-CRP were monitored before and after treatment.Results The IMT decreased obviously in two groups 20 weeks after treatment（P0.05）,and IMT decreased significantly in experimental group compared with control group（P0.05）.Level of TG,TC,LDL-C,LP（a） and hs-CRP decreased,and HDL-C increased significantly in experimental group than those of control group and before treatment（P0.05）.Conclusion Combined application of atorvastatin with clopidogrel has significant effect on lipids regulation and inflammation control,and it can delay the progression of arteriosclerosis in acute coronary syndrome.
出处
《安徽医学》
2011年第8期1118-1120,共3页
Anhui Medical Journal
