Min小鼠疾病“一体化”模型

Integrative model of Min mouse for diseases

Min基因突变小鼠因其肠道多发息肉被认为是人类家族性腺瘤性息肉病(FAP)的理想模型,在肠道肿瘤发生机制方面备受关注,其具有典型的贫血表现,脾肿大明显,同时伴有血细胞比容的明显下降。Min小鼠还具有明显的胸腺萎缩等症状。此外,雌性小鼠如经致癌剂ENU诱导,易发生生殖与内分泌系统异常。由于该小鼠表型明确,可以利用其多种表型特征开展疾病"一体化"模型研究。本文主要从Min小鼠在多个系统表现出来的不同病理特征来进行文献综述并深入阐述"一体化"模型。

Min（multiple intestinal neoplasia） mouse is widely considered as the appropriate model of human familial adenomatous polyposis（familial adenomatous polyposis,FAP） because of bearing multiple intestinal polyps.Thus,the mechanism on intestinal carcinogenesis is highly concerned.In addition,marked splenomegaly and typical anemia will be present,accompanied by a distinct decline in hematocrit.Min mice also have other obvious symptoms such as thymus trophy.The reproductive and endocrine system will lead to be obviously abnormal once treated with carcinogenic agent（e.g.ENU） in the female Min mice.Since the phenotype is clear,Min mouse could be developed into an integrative model based on its wide range of phenotypic characteristics.The present review introduced the pathological symptoms of various systems in Min mice to clarify the new concept on the integrative model.