摘要
目的:研究聚乙二醇干扰素α-2b治疗慢性丙型肝炎(CHC)的疗效与机体免疫状态的关系。方法:采用流式细胞仪检测聚乙二醇干扰素α-2b治疗前后CHC患者T淋巴细胞亚群CD3+、CD4+、CD8+T淋巴细胞及NK(自然杀伤细胞)、CTL(细胞毒性T淋巴细胞)的变化。结果:应答组患者血清CD3+、CD4+T淋巴细胞、NK细胞、CD4+/CD8+比值的上升程度及CD8+、CTL细胞的下降程度明显高于无应答组,而持续应答组又相应优于复发组。结论:聚乙二醇干扰素α-2b治疗后患者的细胞免疫状态明显增强,检测患者T淋巴细胞亚群、NK、CTL细胞的变化,可以预测患者干扰素治疗的疗效。
Objective：To study the realtionship between the immune state and the efficacy of peg-interferon alfa-2b of patients with hepatitis C.Methods：By using flow cytometry,the changes of T lymphocyte subtypes（CD3,CD4,CD8） and NK,CTL from patients with chronic hepatitis C before and after peg-interferon alfa-2b therapy were detected.Results：The variable elevation of serum T lymphocyte subtypes（CD3,CD4）,NK,CD4/CD8 in responder group was higher than that in non-responder groups（P 0.05 for each）.There were a much stronger T lymphocyte subtypes（CD8）,CTL decrease in responder group（P0.05）,and the group of sustained viral response were significantly better than the relapsed group.Conclusion： The cellular immune function of the patients with chronic hepatitis C are markedly increased after treatment of peg-interferon alfa-2b.The changes of T lymphocyte subtypes（CD3,CD4,CD8） 、NK,CTL could predict the curative effect of peg-interferon alfa-2b in chronic hepatitis C.
出处
《中西医结合肝病杂志》
CAS
2011年第4期209-211,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
