凋亡抑制蛋白Survivin在子宫内膜癌组织中的表达及其与ER、PR表达关系的探讨

Study on the expression of Survivin and its correlation with expression of ER and PR in endometrial carcinoma.

目的探讨凋亡抑制蛋白Survivin在子宫内膜癌组织中的表达及其与ER和PR表达的关系。方法采用链霉菌抗生物素蛋白-过氧化物酶连接(SP)免疫组织化学法检测38例子宫内膜癌组织中Survivin、ER和PR的表达,并与子宫内膜非典型增生组织17例及正常子宫内膜组织10例进行比较。结果子宫内膜癌、子宫内膜非典型增生、正常子宫内膜组织中,Survivin的阳性表达率依次为65.8%、58.8%和70%,三者之间差异无显著性(P>0.05)。Survivin的阳性表达与子宫内膜癌患者的年龄、病理分级、手术-病理分期、肌层浸润深度等无相关性(P均>0.05),子宫内膜癌组织中Survivin与ER和PR的阳性表达无相关性(P>0.05)。结论 Survivin可能不是子宫内膜癌的一个特异性指标。

Objective To study the expression of Survivin and its correlation with expression of ER and PR in endometrial carcinoma.Methods Expressions of Survivin,ER and PR were detected by immunohistochemistry in 38 patients with endometrial carcinoma,17 patients with endometrial atypical hyperplasia,and 10 cases of normal human endometrium.Results Survivin was expressed in 25 of 38（65.8%） cases of endometrial carcinoma,in 10 of 17（58.8%） cases of endometrial atypical hyperplasia,and in 7 of 10（70%） cases of human normal endometrium.There were no significant differences of Survivin expression in endometrial carcinoma,endometrial atypical hyperplasia,and normal endometrium.There were no relationship between Survivin expression and FIGO stage,histological grade,the depth of myometrial invasion.There were no significant association between Survivin expression and ER expression,PR expression.Conclusion Survivin perhaps is not a specific marker of endometrial cancer.