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4-氯喹唑啉类化合物的合成

Synthesis of 4-Chloroquinazoline Derivatives
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摘要 以邻氨基苯甲酸类化合物和醋酸脒为原料,经环合反应得到喹唑啉-4(3H)-酮类化合物,再经POCl3氯化后得到4-氯喹唑啉类化合物。所得化合物的结构均经核磁和质谱确证。 Quinazolin-4 (3H)-ones were conveniently synthesized from anthranilie acids and amidines via cyclization reaction, which could be chloridized with POCl3 to obtain 4-chloroquinazoline derivatives. The structures of the products were characterized by 1HNMR and MS.
出处 《浙江化工》 CAS 2011年第8期4-6,9,共4页 Zhejiang Chemical Industry
基金 国家自然科学基金资助项目(20876149)
关键词 4-氯喹唑啉 氯化 邻氨基苯甲酸 喹唑啉-4(3H)-酮 4-chloroquinazoline chlorination anthranilic acid quinazolin-4(3H)-one
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