摘要
目的研究解毒复肾逐瘀方对肾纤维化的干预作用及可能的作用机制。方法运用大鼠单侧输尿管结扎术(UUO)建立肾间质纤维化动物模型,观察解毒复肾逐瘀方治疗后肾间质病理变化及肾组织基质金属蛋白酶2、9(MMP-2、MMP-9)及基质金属蛋白抑制因子(TIMP-1)表达的影响。结果解毒复肾逐瘀方能明显改善大鼠的血尿素氮、肌酐水平(P<0.05),能明显降低肾组织的羟脯氨酸含量。解毒复肾逐瘀方治疗组能抑制大鼠的MMP-9、MMP-2蛋白的表达,促进TIMP-1表达。结论解毒复肾逐瘀方能减轻肾间质纤维化的损伤,可能与恢复肾组织MMP/TIMP的平衡作用有关。
OBJECTIVE To study the intervened function and the potential edtoxification effect of the complex sludge prescription to the renal fibrosis in the kidney.METHODS Rats with unilateral ureteral ligation（UUO） establish an aninal models of renal interstitial fibrosis,were observed under the complex sludge prescription treatment,the renal pathology and renal interstitial matrix metalloproteinase 2、9（MMP-2,MMP-9） and matrix metalloproteinase inhibitor（TIMP-1） presentational effect.RESULTS The recovery of renal detoxification by the complex sludge prescription,rats can significantly improve blood urea nitrogen and creatinine levels（P）,significantly reduced renal tissue levels of hydroxyproline.Detoxification treatment of the complex sludge prescription could inhibit the MMP-1.CONCLUSION The complex sludge prescription for Kidney Detoxification can reduce the damage of renal interstitial fibrosis,which may bear upon the restore renal tissue MMP/TIMP balance effects.
出处
《海峡药学》
2011年第8期39-41,F0003,共4页
Strait Pharmaceutical Journal
基金
福建省中医药重点项目资助
