那格列奈对初诊2型糖尿病患者早时相胰岛β细胞功能影响的研究

A study of the effect of nateglinide in the early phase of type β islet cell function in newly diagnosed type 2 diabetic patients

目的探讨那格列奈对初诊2型糖尿病患者早时相胰岛β细胞功能的影响。方法选择本院初诊为2型糖尿病患者60例,分为观察组和对照组,观察组应用那格列奈,对照组应用阿卡波糖。比较治疗前后胰岛素、血浆糖化血红蛋白水平及胰岛β细胞早分泌指数。结果 (1)治疗后,观察组患者口服糖耐量试验30、60min胰岛素水平较治疗前明显升高(P<0.05),胰岛素分泌于60min达到峰值,180min恢复到较低水平。(2)治疗后,两组患者血浆糖化血红蛋白水平明显低于治疗前(P<0.05),但两组间差异无统计学意义。(3)观察组患者△I30/△G30恢复至10.73,明显高于治疗前及对照组(P<0.05)。结论那格列奈对2型糖尿病患者具有较好的疗效,可以有效地促进早时相胰岛素分泌。

Objective To investigate the effect of nateglinide in the early phase of type β islet cell function in newly diagnosed type 2 diabetic patients. Methods 60 cases type 2 diabetes patients were chosen. They were randomly divided into two groups, the observation group were treated with nateglinide, the control were treat with Acarbose. The Insulin levels and Plasma glyeated hemoglobin levels and △I30/△G30 before after treatment were compared. Results （ 1 ） After treatment, the 30 min and 60 min insulin levels were higher than before （ P 〈 0. 05 ） , the insulin peak were in 60 minutes, they returned to low level in 180 minutes. （2）After treatment, the mean Plasma glycated hemoglo- hiu levels were much lower compared with before （P 〈 0. 05 ） , but there were no significant difference between the two. （3）The patients △I/30/ △G30 restored to 10. 73, significantly higher than before treatment and the control group （P 〈 0. 05）. Conclusions Nateglinide has good effect in the treatment of type 2 diabetes, it can effectively promote the early - phase insulin secretion.