胺碘酮与利多卡因治疗急性心肌梗死后室性心律失常疗效观察

The efficacy of amiodarone and lidocaine on ventricular arrhythmias after acute myocardial infarction

目的:比较胺碘酮与利多卡因治疗急性心肌梗死后室性心律失常的疗效。方法:将92例患者随机分为两组。利多卡因组以利多卡因50mg静注,必要时15min后重复一次至利多卡因总量达150mg,继以1～3mg/min的速度静脉滴注,维持24h。胺碘酮组以胺碘酮150mg于10min内静注,然后以1mg/min静脉滴注6h,再以0.05mg/min维持静滴至稳定后24h。分别判定疗效。结果:胺碘酮与利多卡因组急性心肌梗死后室性心律失常有效率分别为78.2%与60.9%,胺碘酮组的疗效明显高于利多卡因组,差别有统计学意义(P<0.05)。胺碘酮组病死率明显低于利多卡因组,差别有统计学意义(P<0.05)。结论:与利多卡因相比,胺碘酮静脉给药治疗急性心肌梗死后室性心律失常,能增加有效率,减少病死率。

Objective：To evaluare the efficacy of Amiodarone and Lidocaine on ventricular arrhythmias after acute myocardial infarction.Methods：92 example patients divide into two groups stochastically.Lidocaine group by Lidocaine 50mg static note,when necessity after 15min,is redundant one time reaches 150mg to the Lidocaine total quantity,the followed by 1～3mg/min speed vein drop note,maintains 24h.Amiodarone group by Amiodarone 150mg in 10min static note,then vein drop pours 6h by 1mg/the min,again maintains the static drop by 0.05mg/min after the stability 24h.Distinction determination curative effect.Results：Amiodarone and the Lidocaine level to the ventricular arrhythmias after acute myocardial infarction effectiveness respectively are 78.2% and 60.9%,Amiodarone group′s curative effect obvious high than Lidocaine group’s,has statistics significance（P〈0.05）.The Amiodarone group′s mortality rate is lower than the Lidocaine group′s obviously,has statistics significance（P〈0.05）.Conclusion：Amiodarone vein for the medicine treatment ventricular arrhythmias after acute myocardial infarction,can increase effectiveness,reduces the mortality rate.