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食管癌组织中TIMP-2含量对判断预后的价值

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摘要 食管癌是常见的消化道恶性肿瘤,病情进展快,预后较差。因此,寻找能反映食管癌细胞侵袭和转移潜能的标记物己成为研究的热点,明确这些标记物有利于肿瘤的早期诊断、预测病情发展、指导临床治疗及改善预后。基质金属蛋白酶组织抑制剂TIMP-2是细胞外基质降解过程中的重要酶类,与肿瘤的侵袭和转移有密切关系。本研究采用免疫组织化学法对食管癌的癌组织、正常组织TIMP-2的表达进行研究,并进一步探讨其与食管癌浸润、转移、预后的关系,现报告如下:
作者 钟立哲
出处 《中国民康医学》 2011年第16期1978-1978,2004,共2页 Medical Journal of Chinese People’s Health
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  • 1李杰茹,齐凤英,左连富,李丽,李子良.MMP-2与TIMP-2的比值与食管癌侵袭转移的关系[J].肿瘤防治杂志,2005,12(14):1083-1086. 被引量:9
  • 2王宪远,何炜,许迎朝.基质金属蛋白酶-9与食管鳞癌预后的关系[J].河南医学研究,2005,14(3):235-236. 被引量:6
  • 3BACHMEIER B E,IANCU C M,JOCHUM M,et al.Matrix metal-loproteinases in cancer:comparison of known and novel aspects of their inhibitionas a therapeutic approach[J].Expert Rev Anticancer Ther,2005,5(1):149-163.
  • 4SHARMA R,CHATTOPADHYAY T K,MATHUR M,et al.Prognostic significance,of stromelysin-3 and tissue inhibitor of matrix metalloproteinase-2 in esophageal cancer[J].Oneology,2004,67(3-4):300-309.
  • 5AKIHIRO K,NOBUYUKI B,KAN K,et al.Expressions of Matrix Metalloproteinases in Early-Stage Oral Squamous Cell Carcinoma as Predictive Indicators for Tumor Metastases and Prognosis[J].Clinical Cancer Research,2004,10:634-640.
  • 6YONEMURA Y,ENDOUY,FUJITA H,et al.Role of MMP-7 in the formation of peritoneal dissemination in gastric cancer[J].Gastric Cancer,2000,3(2):63-70.
  • 7LIU X P,KAWAUCHI S,OGA A,el al.Prognostic significance of matrixm elalloproteinase-7(MMP-7) expression at the invasive front in gastric carcinoma[J].Jpn J Cancer Res,2002,93(3):291-295.
  • 8SALMELA M T,KARJALAINEN LINDSERG M L,PUOLAKKAINEN P,el al.Upregulation and diferential expression of matrily-sin(MMP-7) and metalloelastase (MMP-12) and their inhibitors TIMP-1 and TIMP-3 in Barrett S oesophageal adonocarcinoma[J].Br J Cancer,2001,85(3):383-392.
  • 9NAGLICH J G,JURE KUNKEL M,GUPTA E,et al.Trail Inhibition of Angiogenesis and Metastasis in Two Murine Models by the Matrix Metalleelastase Inhibitor,BMS-275291[J].Cancer Res,2001,61(23):8480-8485.
  • 10NAKAMURA E S,KOIZUMI K,YAMAURA T,el al.Antitumor Angiogenie effect of Matrix Melalleelastase Inhibitor MMI270[J].Anticaneer Ras,2003,23(1A):411-417.

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