摘要
目的探讨二苯乙烯对2型糖尿病降血糖作用。方法50只Wistar雄性大鼠随机分为模型组(n=40)和对照组(n=10)。模型组大鼠口服脂肪乳20ml/kg,连续40d,分别在第4l、42天时模型组大鼠腹腔注射链脲佐菌素120mg/kg、100mg/kg,各1次。建立模型后,将模型组大鼠随机分为4组,每组10只。分别灌胃给予二苯乙烯500mg/kg、200mg/kg、100mg/kg和二甲双胍100mg/kg。全自动生化分析仪测定血糖、血脂水平;分光光度计测肝糖元含量。结果建模后,大鼠的血糖(Glu)、甘油三酯fTG)、总胆固醇(TC)、低密度脂蛋白(LDL.c)、高密度脂蛋白(HDL.c)水平分别升高140.89%、25.77%、275.52%、105.54%和31.25%(P〈0.01);给予模型组大鼠二苯乙烯20d后,血糖和血脂水平比给药前降低(P〈0.05),肝糖元含量比对照组增加8.06%~16.17%。结论二苯乙烯具有降低2型糖尿病大鼠血糖和血脂、增加肝糖元含量的作用。
Objective To study the effect of stilbene on blood glucose of rats with type 2 diabetes. Methods 50 male Wistar rats were randomly divided into model group (n-40) and control group (n=10). The model group was given fat emulsion 40 days continuously with 20 ml/kg, po, and streptozotocin with 120 mg/kg on the 41st day, 100 mg/kg on the 42nd day, i.p. After the modeling, the model group was divided into 4 groups with 10 in each. They were given stilbene with 500 ml/kg, 200 ml/kg, 100 ml/kg and metformin with 100 mg/kg, ip, respectively. The level of blood glucose, blood lipid and glycogen content were determined. Results After the modeling, the blood glucose and TG, TC, LDL-C, HDL-C increased by 140.89%, 25.77%, 275.52%, 105.54% and 31.25% respectively (P〈0.01); after stilbene was given, the level of blood glucose and lipid decreased significantly (P〈0.05), the liver glycogen content increased significantly by 8.06% 16.17% compared to the control group. Conclusion Stilbene can decrease the concentration of blood glucose and lipid, and increase the liver glycogen content of rats with type 2 diabetes.
出处
《中国康复理论与实践》
CSCD
2011年第8期745-747,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
甘肃省自然科学基金项目(0803RJZA052)
甘肃省证据科学技术研究与应用重点实验室(培育基地)科技计划项目(ZDSYS-Y17)
关键词
二苯乙烯
2型糖尿病
血糖
血脂
stilbene
type 2 diabetes
blood glucose
lipid