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有氧运动对冠心病患者内皮功能的影响 被引量:7

Effects of aerobic exercise on endothelial function in patients with coronary heart disease
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摘要 目的:观察有氧运动对冠心病患者内皮功能的影响。方法:入选60例平时缺乏运动的冠心病患者,随机均分为运动干预组和药物治疗组,运动干预组进行有氧运动,每周5次,每次30 min。药物治疗组给予美托洛尔、硝酸甘油等药物治疗。各组干预12周,干预前后采用酶联免疫吸附试验法测定血清细胞间粘附分子-1(ICAM-1)和白介素-18(IL-18)水平,酶法测定一氧化氮(NO)水平。另选20例健康体检者作为正常对照组。结果:与健康人比较,冠心病患者血清ICAM-1[(246.43±39.32)ng/ml比(335.03±61.99)ng/ml]和IL-18[(230.60±29.15)pg/ml比(308.67±48.08)pg/ml]水平明显升高,NO[(80.34±13.22)μmol/L比(48.54±7.64)μmol/L]水平明显降低(P均<0.01)。与治疗前比较,经12周运动干预后,ICAM-1[(333.47±57.29)ng/ml比(304.66±45.58)ng/ml]和IL-18[(310.82±47.37)pg/ml比(290.18±38.47)pg/ml]水平明显下降,NO[(49.88±7.90)μmol/L比(54.00±8.83)μmol/L]水平明显升高(P<0.05)。运动干预与药物治疗效果相当(P>0.05)。结论:长期规律有氧运动能够显著改善冠心病患者的内皮功能。 Objective:To explore the effects of aerobic exercise on endothelial function in patients with coronary heart disease(CHD).Methods:A total of 60 CHD patients lacked of exercises were randomly and equally divided into exercise intervention group(performed aerobic exercise,30 min 5 times/week) and medicinal treatment group(received medicinal treatment with metoprolol and nitroglycerol).Both groups were treated for 12 weeks.Enzyme linked immunosorbent assay was used to measure serum levels of intercellular adhesion molecule-1(ICAM-1) and interleukin-18(IL-18),and level of nitric oxide(NO) was measured by enzyme method.Another 20 healthy subjects were selected as normal control group.Results:Compared with normal controls,serum levels of ICAM-1 [(246.43±39.32)ng/ml vs.(335.03±61.99) ng/ml] and IL-18 [(230.60±29.15) pg/ml vs.(308.67±48.08) pg/ml] significantly increased,level of NO [(80.34±13.22) μmol/L vs.(48.54±7.64) μmol/L] significantly decreased in CHD patients,P〈0.01 all.Compared with before treatment,after 12-week exercise intervention,levels of ICAM-1 [(333.47±57.29) ng/ml vs.(304.66±45.58) ng/ml] and IL-18 [(310.82±47.37) pg/ml vs.(290.18±38.47) pg/ml] significantly decreased,and level of NO [(49.88±7.90) μmol/L vs.(54.00±8.83) μmol/L] significantly increased in exercise intervention group,P〈0.05 all.Effect of exercise intervention was equal with that of medicinal treatment(P〉0.05).Conclusion:Long-term regular aerobic exercise can significantly improve endothelial function of patients with coronary heart disease.
出处 《心血管康复医学杂志》 CAS 2011年第4期297-300,共4页 Chinese Journal of Cardiovascular Rehabilitation Medicine
基金 2007年常熟市卫生局课题
关键词 冠状动脉疾病 运动 细胞粘附分子 白细胞介素18 Coronary artery disease Exercise Cell Adhesion Molecules Interleukin-18
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