代谢综合征患者血浆线粒体偶联因子-6含量变化

Changes of plasma level of mitochondrial coupling factor-6 in patients with metabolic syndrome

目的:研究代谢综合征(MS)患者血浆线粒体偶联因子-6(CF-6)含量的变化。方法:选择我院住院MS患者100例为MS组,健康成人20例为正常对照组,用放射免疫方法测定所有研究对象静脉血浆中CF-6浓度并进行比较。结果:MS组患者外周静脉血浆CF-6浓度较正常对照组明显升高[(358±51)pg/ml比(265±40)pg/ml,P<0.01],且MS组各亚组CF-6浓度均明显高于正常对照组(P均<0.01)。结论:代谢综合征患者血浆线粒体偶联因子-6浓度明显升高,在代谢综合征的发病中具有一定的病理生理意义。

Objective：To investigate change of plasma level of mitochondrial coupling factor-6（CF-6） in patients with metabolic syndrome（MS）.Methods：A total of 100 MS inpatients from our hospital were enrolled as MS group and another 20 healthy adults were regard as normal control group.Venous plasma CF-6 levels were determined by radioimmunoassay in all subjects and the results were compared then.Results：Plasma level of CF-6 in peripheral vein was significantly higher in MS group than that of normal control group [（358±51） pg/ml vs.（265±40） pg/ml,P〈0.01],and concentrations of CF-6 in subgroups of MS group were significantly higher than that of normal control group（P〈0.01 all）.Conclusion：Plasma concentration of mitochondrial coupling factor-6 significantly increases in patients with metabolic syndrome,and it possesses pathophysiological significance in onset of metabolic syndrome.