重组脑利钠肽治疗对急性心肌梗死大鼠心功能的影响

Effects of brain natriuretic peptide on cardiac function of rats with acute myocardial infarction

目的:探讨早期重组人脑利钠肽(rhBNP)治疗对大鼠急性心肌梗死(AMI)后心功能的影响。方法:结扎大鼠左前降支,建立AMI模型,存活的大鼠被随机分为AMI对照组(20只)和rhBNP治疗组(20只),另设假手术组(15只)。rhBNP治疗组给予1周BNP治疗,AMI对照组和假手术组仅以等体积生理盐水静脉注射,2周后观察rhBNP对心功能的影响。结果:与假手术组相比,AMI对照组左室舒张末期内径(LVEDd)明显增加[(4.4±0.3)mm比(7.7±0.3)mm],左室射血分数[LVEF,(82±5)%比(42±10)%]和左室短轴缩短率[FS,(50±5)%比(18±6)%]明显减少(P<0.05);经BNP治疗后,BNP组LVEDd[(6.4±0.4)mm]、LVEF[(51±7)%]、FS[(29±7)%]均较AMI对照组明显改善(P<0.05)。结论:早期重组人脑利钠肽治疗急性心肌梗死可以有效改善心脏功能。

Objective：To explore effects of early recombinant human brain natriuretic peptide（rhBNP） treatment on cardiac function of rats after acute myocardial infarction（AMI）.Methods：AMI model was established by ligating left anterior descending artery of rats.Survived rats were randomly divided into AMI control group（n=20） and rhBNP treatment group（n=20）,and another 15 normal rats were enrolled as sham operation group.Rats in rhBNP treatment group were treated with rhBNP for a week,and AMI control group,sham operation group were treated with intravenous injection of physiological saline of same volume.Effects of rhBNP on cardiac function were observed and analyzed after two weeks.Results：Compared with sham operation group,left ventricular end-diastolic dimension [LVEDd,（4.4±0.3）mm vs.（7.7±0.3）mm] significantly increased,left ventricular ejection infraction [LVEF,（82±5）% vs.（42±10）%] and fractional shortening [FS,（50±5）% vs.（18±6）%] significantly decreased in AMI control group（P〈0.05）;After treated with rhBNP,LVEDd [（6.4±0.4）mm],LVEF[（51±7）%] and FS[（29±7）%] significantly improved in rhBNP treatment group compared with AMI control group（P〈0.05）.Conclusion：Early treatment with recombinant human brain natriuretic peptide can effectively improve cardiac function in rats with acute myocardial infarction.