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Rho/Rho激酶信号通路与脉管收缩 被引量：2

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摘要 Rho/Rho激酶信号通路在正常血管、淋巴管等脉管收缩过程中发挥重要的调节作用,并参与休克后血管反应性和钙敏感性的双相调节以及休克淋巴管低反应性的发生。以Rho/Rho激酶为靶点,对于干预休克脉管系统低反应性的发生具有重要意义。本文综述Rho/Rho激酶信号通路在脉管收缩中的调节机制。
作者 司永华 牛春雨 赵自刚
机构地区 河北北方学院微循环研究所基础医学院病理生理教研室
出处 《生理科学进展》 CAS CSCD 北大核心 2011年第4期311-313,共3页 Progress in Physiological Sciences
基金 国家自然科学基金(30370561 30770845 30971203) 河北省自然科学基金(C2004000649 C2008000503) 河北省教育厅科学研究重点项目(ZH2007101)资助课题
关键词 RHO/RHO激酶信号通路 收缩性 血管 淋巴管
分类号 R331.4 [医药卫生—人体生理学]
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参考文献15

  • 1Li T, Liu L, Liu J, et al. Mechanisms of Rho kinase regula- tion of vascular reactivity following hemorrhagic shock in rats. Shock, 2008, 29 : 65 -70.
  • 2Hosaka K, Mizuno R, Ohhashi T. Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump ac- tivity in isolated lymph vessels. Am J Physiol Heart Circ Physiol, 2003, 284 : H2015 - H2025.
  • 3Ogut O, Brozovich FV. Regulation of force in vascular smooth muscle. J Mol Cell Cardiol, 2003, 35 : 347 355.
  • 4Somlyo AV. New roads leading to Ca2+ sensitization. Circ Res. 2002. 91 : 83-84.
  • 5Oertle T, van der Haar ME, Bandtlow CE, et al. Nogo-A inhibits neurite outgrowth and cell spreading with three dis- crete regions. J Neurosci, 2003, 23 : 5393 - 5406.
  • 6Kitazawa T, Eto M, Woodsome TP, et al. Phosphorylation of the myosin phosphatase targeting subunit and CPI-17 dur- ing Ca2+ sensitization in rabbit smooth muscle. J Physiol, 2003, 546 : 879 - 889.
  • 7Muranyi A, Derkach D, Erdodi F, et al. Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target sub- unit: inhibitory effects and occurrence in A7r5 cells. FEBS Lett, 2005, 579 : 6611 -6615.
  • 8Somlyo AP, Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kina- ses, and myosin phosphatase. Physiol Rev, 2003, 83 . 1325 - 1358.
  • 9Li T, Liu L, Xu J, et al. Changes of Rho kinase activity af- ter hemorrhagic shock and its role in shock-induced biphasie response of vascular reactivity and calcium sensitivity. Shock, 2006, 26 : 504- 509.
  • 10Brzeska H, Szczepanowska J, Matsumura F, et al. Rac - induced increase of phosphorylation of myosin regulatory light chain in HeLa cells. Wiley Online Library, 2004, 58 : 186 - 199.

二级参考文献22

  • 1赵自刚,牛春雨,张静,樊贵,王淑强,王玉珍.肠系膜淋巴管结扎对MODS大鼠的器官保护作用[J].中国病理生理杂志,2005,21(2):308-313. 被引量：23
  • 2牛春雨,赵自刚,张静,樊贵.肠淋巴途径在二次打击致大鼠MODS的发病学作用[J].中国病理生理杂志,2005,21(3):559-564. 被引量：18
  • 3徐竞,刘良明.参与失血性休克血管钙敏感性调节的信号分子[J].中国病理生理杂志,2006,22(5):896-899. 被引量：12
  • 4牛春雨,赵自刚,李继承,陈瑞华,张静,张玉平,孙黎.休克淋巴液对大鼠肺微血管内皮细胞的损伤作用[J].分子细胞生物学报,2007,40(2):145-152. 被引量：10
  • 5Zhang J,Liu YK.Changes of mesenteric lymph microcirculation and intestinal lymph circulation during shock in rat[J].Lymphology,1994,27(Suppl):721-724.
  • 6Yasuda A,Ohshima N.In situ observations of spontaneous contractions of the peripheral lymphatic vessels in the rat mesentery:Effects of temperature[J].Experientia,1984,40(4):342-343.
  • 7Goto Y,Kato T.On the quantitative experssion of mesenterial micro-lymphatic dynamics in the rat influenced by endotoxin[A].In:Tsuchiya M.ed.Microcirculation-an update[M].Vd 1.Amsterdam:Elsevier,1987.571-572.
  • 8Tunctan B,Korkmaz B,Dogruer ZN,et al.Inhibition of extracellular sigual-regulated kinase(ERK1/2)activity reverses endotoxin-induced hypotension via decreased nitric oxide production in rats[J].Pharmacol Res,2007,56(1):56-64.
  • 9Zhao G,Zhao Y,Pan B,et al.Hypersensitivity of BKCa to Ca2+sparks underlies hyporeactivity of arterial smooth muscle in shock[J].Circ Res,2007,101(5):493-502.
  • 10Mansart A,Bollaert PE,Giummelly P,et al.Effects of dexamethasone and L-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock[J].Am J Physiol Heart Circ Physiol,2006,291(3):H1177-H1182.

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生理科学进展
2011年 第4期

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