回旋加速器日连续2次生产^(18)F-离子时产量差异分析

Difference Analysis of Continual ^(18)F- ion Production Twice a Day by Cyclotron

目的:分析利用美国通用电气公司的小型回旋加速器MINItrace,通过核反应18O(p,n)18F,日连续生产2次18F-离子时,发现第二批次生产出来的18F-离子活度略高于第一次,设计在控制各项生产条件都相同的情况下,探究第二批次生产的18F-离子活度是否高于第一次。方法:按照18F-FDG生产标准规程,日连续生产2次18F-离子,控制各项生产条件(包括轰靶的束流大小、时间长短、18O-H2O批次等)相同,共进行10组实验。使用SPSS17.0软件,对统计的2次18F-离子活度的数据进行配对样本t检验,分析2次生产差异是否有统计学意义。结果:第二次生产出来的18F-离子放射性活度高于第一次,第一次生产的18F-离子活度为(746.24±11.75)mCi,第二次生产的18F-离子活度为(831.45±54.05)mCi,2次生产的差别具有统计学意义,P<0.005。结论:在生产条件相同的条件下,回旋加速器一天内连续2次生产18F-离子时,第二批次生产出的18F-离子活度高于第一次。

Objective G.E. Minitrace Cyclotron was used to produce 18F- ion twice a day with nuclear reaction 18O（p, n）18F. The 18F- ion activities of the second time were statistically higher than the first time when the conditions of production were different. This study assessed whether the 18F- ion activities of the second time were higher than the first time when the conditions of production were control. Methods 18F- ion was produced twice a day when the conditions of production, including the irradiation current, the irradiation time and the batch of 18O-H2O, were control. The results were analyzed to show whether the 18F- ion activities of the second time in ten days were statistically higher than the first time using paired samples T-test by SPSS 17.0. Results The mean 18F- ion activity of the second time was 831.45±54.05mCi, which was higher than that of the first time （746.24±11.75mCi） （P0.005）. Conclusion When the conditions of production are control, the 18F- ion activities of the second time are higher than the first time. The influence factors include the 18O-H2O concentration in the cavity of target, the remnant 18F- ion in the tube and filter transferring to the target bottle at the second production and air humidity.