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右美托咪定在长途转运危重患者镇静中的临床应用

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摘要 目的:评估右美托咪定在长途转运危重患者救护治疗中的效果及安全性。方法:140例从下级医院转入我院治疗的危重患者应用右美托咪定镇静,控制镇静水平RamsayⅢ~Ⅳ级,以咪达唑仑作为对照,分别记录镇静起效时间、平均负荷剂量、维持剂量、停用镇静剂后苏醒时间及不良反应的发生率。结果:与咪达唑仑比较,右美托定起效迅速[(59.7±7.2)svs(119.6±14.2)s,P<0.05],镇静的同时保持可唤醒能力[苏醒时间(0.30±0.04)minvs(12.2±3.0)min,P<0.05],治疗剂量内不诱发临床意义的呼吸抑制(发生率0.18%,P<0.05),血流动力学影响小(平均血压降低2.5%,心率减慢3.0%)。结论:右美托咪定是长途转运危重患者镇静的良好选择,提高了危重患者转运成功率。
作者 粟英
出处 《求医问药(下半月刊)》 2011年第8期236-237,共2页 Seek Medical and Ask The Medicine
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参考文献7

  • 1MantzJ.Dexmedetomidine. DrugsToday (Barc) . 1999
  • 2Gertler R,Brown HC,MitchellDHet al.Dexmedetomidine:a novel sedative-analgesic agent. Proc (Bayl Univ Med Cent) . 2001
  • 3Jen A. Tan,Kwok M. Ho.Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis[J]. Intensive Care Medicine . 2010 (6)
  • 4Venn RM,,Hell J,Grounds RM.Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care. Journal of Critical Care . 2000
  • 5Martin E,,Ramsay G,Mantz J, et al.The role of the alpha-2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit. Journal of Intensive Care Medicine . 2003
  • 6Gerlach AT,Dasta JF.Dexmedetomidine:an updated review. Annals of Pharmacotherapy . 2007
  • 7彭绵,方伟强,余雪涛,蔡举瑜.右美托咪定在重症监护病房镇静中的临床应用[J].中国急救医学,2011,31(3):197-199. 被引量:25

二级参考文献15

  • 1Mantz J. Dexmedetomidine [ J ]. Drugs Today ( Barc), 1999, 35 (3) : 151 -157.
  • 2Gertler R, Brown HC, Mitchell DH, et al. Dexmedetomidine: a no- vel sedative - analgesic agent [ J ]. Proc ( Bayl Univ Med Cent) , 2001, 14(1): 13-21.
  • 3Martin E, Ramsay G, Mantz J, et al. The role of the alpha 2 - adrenoceptor agonist dexmedetomidine in postsurgical sedation in the in- tensive care unit [ J ]. J Intensive Care Med, 2003, 18 ( 1 ) : 29 - 41.
  • 4Nelson LE, Lu J, Guo T, et al. The alpha 2 - adrenoceptor agonist dexmedetomidine converges on an endogenous sleep - promoting path- way to exert its sedative effects [ J ]. Anesthesiology, 2003, 98 (2) : 428 - 436.
  • 5Gerlach AT, Dasta JF. Dexmedetomidine: an updated review[ J ]. Ann Phannacother, 2007, 41 (2): 245 -252.
  • 6Tan JA, Ho KM. Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta- analysis [ J ]. Intensive Care Med, 2010, 36(6) : 926 -939.
  • 7Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomi- dine in the surgical patient requiring intensive care [ J 1 - Crit Care, 2000, 4(5) : 302 -308.
  • 8Shehabi Y, Nakae H, Hammond N, et al. The effect of dexmedeto- midine on agitation during weaning of mechanical ventilation in critically ill patients[J]. Anaesth Intensive Care, 2010, 38( 1 ) : 82 - 90.
  • 9Reade MC, O'Sullivan K, Bates S, et al. Dexmedetomidine vs. halo- peridol in delirious, agitated, intubated patients: a randomised open -label trial[J]. Crit Care, 2009, 13(3) : R75.
  • 10Riker RR, Shehabi Y, Bokesch PM, et al. Dexmedetomidine vs mi- dazolam for sedation of critically ill patients: a randomised trial[ J ]. JAMA, 2009, 301 (5) : 489 -499.

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