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PPARγ及其配体与类风湿关节炎的研究进展 被引量：1

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摘要 过氧化物酶体增殖物激活受体(Peroxisome proliferater-activated receptor,PPAR)是一类由配体活化的核转录因子,属于细胞核受体超家族。PPAR被配体激活后参与体内多种生理及病理生理过程,对调节体内的多种代谢过程有重要作用。本文综述了PPARγ的结构及其组织分布、配体、相关信号转导途径以及类风湿关节炎的近年概况,并在此基础上,提出了PPARγ信号通路对类风湿关节炎发病机制的作用,为疾病治疗寻找靶点。
作者 郑可 崔向军
机构地区 三峡大学第一临床医学院 宜昌市中心人民医院风湿免疫科
出处 《海南医学》 CAS 2011年第16期110-112,共3页 Hainan Medical Journal
基金 湖北省自然科学基金(编号:2009CDB113)
关键词 PPARΓ 信号转导 类风湿关节炎
分类号 R593.22 [医药卫生—内科学]
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参考文献21

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二级参考文献26

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海南医学
2011年 第16期

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