齐墩果烷三萜类化合物的抗肿瘤活性及机制研究进展

Advances in Research on Oleanane Triterpenoids and Their Mechanism of Anti-tumor Activities

齐墩果烷三萜类化合物具有广泛的生物活性,其中包括抗肿瘤活性。近年来的研究显示,该类化合物对肿瘤细胞的促凋亡作用与肿瘤细胞线粒体途径的激活密切相关。介绍了齐墩果烷三萜类化合物的抗肿瘤活性,以及该类化合物激活肿瘤细胞凋亡线粒体途径的机制,为进一步探究该类化合物的作用机制及相关药物研发提供参考。

Recently, more and more attention has been paid to oleanane triterpenoids which have a variety of biological activities. There are increasing research reports about their anti-tumor activities, which have been linked to the activation of mitochondria apoptosis pathway. The anti-tumor activities of oleanane triterpenoids and their mechanisms of activating mitochondrial apoptosis pathway in tumor ceils were introduced, so as to provide a reference for the further elucidation of their pharmacological mechanisms and the related drug developments.