脓毒症心脏自主神经功能障碍研究进展

Research progress on sepsis-induced cardiac autonomic nervous system dysfunction

脓毒症是诱发脓毒性休克,多器官功能障碍综合征的重要原因,病死率高,目前仍是危重病领域关注的问题之一。脓毒症合并心功能不全非常常见,其机制尚未完全阐明。目前认为脓毒症患者自主神经系统功能障碍是脓毒症并发心血管功能障碍的机制之一。该文以心血管自主神经调控为切入点,对脓毒症心脏自主神经系统功能障碍的表现、引起心脏自主神经系统功能障碍的机制及相关干预措施进行综述,以期为脓毒症的研究和防治提供理论依据。

Sepsis with its high mortality,was an important etiology of septic shock and multiple organ dysfunction syndrome.It remains one of the research focuses in critical care areas.Cardiac dysfunction is common in patients with sepsis,and its pathogenesis remains incompletely clear.Nowadays,autonomic nervous system dysfunction is considered one of the mechanisms of sepsis-induced cardiovascular dysfunction.In this review,we will expatiate on the cardiovascular autonomic control mechanism,the manifestation and pathogenesis of sepsis-induced cardiac autonomic nervous system dysfunction.Furthermore,some intervention measures in sepsis-induced cardiac autonomic nervous system dysfunction was introduced.We hope to provide theory basis in the prevention and treatment of sepsis.