乳腺癌病人外周血中Mammaglobin、CEA、P53的表达及其意义

Significance of the expression of mammaglobin,CEA,P53 in peripheral blood of breast cancer patients

目的通过检测乳腺癌患者外周血中mammaglobin、CEA、P53的表达情况,探讨mammaglobin、CEA、P53与乳腺癌发生、发展的关系。方法使用实时PCR(realtime RT-PCR)方法检测正常乳腺组织、乳腺原位癌、浸润性乳腺癌患者的外周血中mam-maglobin、CEA、P53的表达,并将mammaglobin的表达情况与后两者进行对比。结果 14例乳腺癌病人外周血中10例mam-malobin、CEA、P53高表达,4例无异常表达;3例原位癌中有2例高表达,1例无异常表达;4例乳腺纤维腺瘤、乳腺病病人外周血中mammalobin、CEA、P53均无异常表达。结论 mammaglobin是乳腺癌的特异性标志物,与乳腺癌的发生有密切的关系,mammaglobin结合CEA、P53联合检测可能会成为乳腺癌患者早期诊断及判断乳腺癌患者预后的特异性标记物。

Aim To detect the expression of mammablogin,CEA,P53 in peripheral blood of the patients of breast cacer,and to explore the relationship between mammaglobin and the occurrence and the development of breast cancer.Methods The expression of mammaglobin,CEA,P53 were detected in peripheral blood of normal tissue of breast,breast cancer of insitu and breast cancer by using RT-PCR,and the expression of mammaglobin was compared with CEA,p53.Results Of 14 cases of breast cacinamo patients,10 cases highly expressed mammaglobin,CEA,P53 in peripheral blood,wihle 4 cases did not 2 cases of in siut cacinoma highly expressed,while all 4 cases of benign breast disease did not highly express these three markers.Conclusion Mammaglobin is a specific marker of the breast cancer,which has colse relation to breast cancer.Mammaglobin together with CEA and P53 will be markers of early dignosis and prognosis of breast cancer.