赛百纤溶酶联合高压氧治疗对脑梗死急性期凝血功能及预后的影响

Influence of plasminogen combined hyperbaric oxygen therapy on prognosis and coagulation in patients with acute cerebral infarction

目的探讨纤溶酶联合高压氧治疗对脑梗死急性期凝血功能及预后的影响。方法 86例急性脑梗死患者随机分为2组,分别给予纤溶酶联合高压氧治疗(高压氧组,n=40)和非高压氧治疗(非高压氧组,n=46),分析2组患者的凝血功能、神经功能缺损评分及总体疗效。结果治疗后高压氧组总有效率(92.5%)显著高于非高压氧组(73.9%),差异有统计学意义(P<0.05)。2组治疗后与治疗前比较,PT、APTT延长,TT缩短,Fib含量下降,神经功能缺损评分降低,差异均有统计学意义(P<0.05),且高压氧组优于非高压氧组(P<0.05)。结论纤溶酶联合高压氧治疗对脑梗死急性期的凝血功能、神经功能缺损评分及总体疗效有明显改善,且安全性高。

Objective To investigate the influence of plasminogen combined hyperbaric oxygen therapy on prognosis and coagulation in patients with acute cerebral infarction.Methods 86 patients with acute cerebral infarction were randomly divided into two groups,hyperbaric oxygen combined fibrinolytic therapy（HBD group,n =40 cases） and hyperbaric oxygen therapy（non-HBO group,n=46 cases） were given respectively.Indexes of two groups of patients with coagulation,neurological deficit score and overall efficacy were recorded and analyzed.Results After treatment,the total efficacy in hyperbaric oxygen group（92.5%） was significantly higher than non-HBO group（73.9%）,the difference was statistically significant （P0.05）.compared with before treatment,PT,APTT prolonged,and TT shortened in the 2 groups after treatment.Fib levels decreased and neurological deficit scores were significantly lower,the differences between them were statistically significant （P0.05）,the hyperbaric oxygen group were superior to the non-HBO group（P0.05）.Conclusion Plasmin combined hyperbaric oxygen therapy is a effective and safe method on the coagulation of acute cerebral infarction,the neurological deficit score and overall effect were improved obviously.