抑郁症患者治疗前后执行功能变化的研究

Change of executive function before and after treatment in depressive disorder patients

目的探讨抑郁症患者治疗前后执行功能的变化。方法 60例抑郁症患者(抑郁组)于治疗前和治疗8周末进行威斯康星卡片分类测验(WCST)、Stroop色词测验、汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)评定,同时设健康对照组60例进行比较。结果抑郁组治疗前WCST测查评分较健康对照组差(P<0.01);治疗后较治疗前有显著改善(P<0.01)。Stroop测查抑郁组治疗前Stroop-CW正确数、Stroop-CW改正数较健康对照组差(P<0.05,P<0.01);治疗后有改善,但与治疗前比较差异无统计学意义(P>0.05);Stroop测查抑郁组治疗后Stroop-CW正确数、改正数仍较健康对照组差(P<0.05,P<0.01)。结论抑郁障碍患者发病期存在执行功能障碍,治疗后执行功能障碍随症状改善而改善,但仍低于健康对照组。

Objective To investigate the variance of executive function in depressive disorders patients after treatment. Methods Sixty depressive disorders patients was analyzed by Wisconsin card sorting test（WCST）,Stroop chromo word test,Hamilton＇s depression scale（HAMD-17）,Hamilton anxiety scale（HAMA） before treatment and 6 weeks after treatment.60 normal healthy people was enrolled as control group.Results Wisconsin card sorting test grade of depressive disorders group was lower than that of normal control group before treatment（P0.01 ）;and which after treatment was signi ficantly improved compared before treatment（P0.01 ）,the Stroop chromo word test correction value,the Stroop chromo word test right value in depressive disorders group was lower than normal control group before treatment（P0.05,P0.01 ）;it was amended after treatment,but there was not statistical significance（P0.05）.The Stroop chromo word right value and the Stroop chromo word test correction value in depressive disorders groups grade was still lower than normal control groups after treatment（P0.05,P0.01 ）.Conclusion It demonstrated that the depressive disorders complicated with executive functional disturbance,furthermore,it was amended with treatment,while it was still lower than the normal control groups.