注射用血塞通冻干粉联合常规方法治疗急性期脑梗死临床疗效及对血浆C反应蛋白的影响

Xue Sai Tong injection plus routine therapy for acute cerebral infarction and the influence on plasma C-reactive protein

目的观察注射用血塞通冻干粉联合常规方法治疗急性期脑梗死的临床疗效及其对血浆C反应蛋白(C-reac-tive protein CRP)的影响。方法 60例急性期脑梗死患者按数字随机法分为治疗组(注射用血塞通加常规治疗)和对照组(常规治疗)各30例,采用美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)比较两组患者治疗前后神经功能缺损改善情况,并测定两组患者治疗前后血浆CRP水平。结果组内治疗前后及治疗后组间NIHSS评分比较,差异均有统计学意义(P<0.05);治疗组和对照组总有效率分别为93.3%和70.0%,差异有统计学意义(P<0.05);两组治疗后CRP水平均较治疗前下降,差异有统计学意义(P<0.05),治疗组下降明显低于对照组,差异有统计学意义(P<0.05)。结论 注射用血塞通冻干粉针联合常规方法治疗急性期脑梗死疗效确切,治疗两周后神经功能缺损有改善,同时对血浆CRP水平有明显降低作用。

Objective To observe the clinical effect of Xue Sai Tong injection plus routine therapy and the influence on plasma C-reactive protein level in acute cerebral infarction patients.Methods Sixty patients were randomly divided into treatment group（Xue Sai Tong plus routine therapy,n=30） and control group（routine therapy,n=30）.Clinical efficacy and the level of C-reactive protein were tested by National Institute of Health Stroke Scale（NIHSS） before and after treatment.Results After treatment,the NIHSS scores of the two groups were significantly different that those before treatment.And difference between the two groups was statistically significant（P0.05）.The total effective rates of the treatment group and the control group were 93.3% and 70.0%（P0.05）.The plasma C-reactive protein of both two groups decreased significantly after treatment（P0.05）.The treatment group decreased more significantly than the control group（P0.05）.Conclusions Xue Sai Tong injection is an effective medicine in the treatment of acute cerebral infarction.After two-week treatment with Xue Sai Tong,neurologic impairment is improved,and the level of plasma C-reactive protein decreases significantly.