奥美拉唑对十二指肠溃疡幽门螺杆菌分布的影响

Omeprazole makes the location of Helicobacter pylori(Hp)in stomach of duodenal ulcer

目的探讨奥美拉唑对十二指肠溃疡患者胃内幽门螺杆菌分布的影响。方法分析我院幽门螺杆菌感染的58例患者的胃镜活检组织切片,活检部位分别为窦小弯及体大弯,观察窦体两部位幽门螺杆菌的检出率、密度及胃炎活动程度的变化。结果①胃窦区用药前、用药后4周及3个月幽门螺杆菌的检出率分别为98.3%、60.3%和68.8%,差异具有统计学意义(P<0.05)。②胃体大弯用药后4周和3个月幽门螺杆菌的密度较用药前增加(P<0.05)。结论奥美拉唑可使幽门螺杆菌在胃内的定植部位发生改变。

Objective To explore the effect of omeprazole for the distribution of Helicobacter pylori in patients with duodenal ulcer.Methods To analyze the biopsy tissue section of the Hp carriers in our hospital.The domain for biopsy was gastric antrum,gastric corpus,and greater gastric curvature,respectively.We observed the detection rate of Hp,optical density,and change of degree of gastritis activity.Results ①For gastric antrum,the detection rate of Hp was 98.3%,60.3% and 68.8% before medication,4 weeks after medication and 3 months after medication,respectively（P〈0.05）.②The optical density of Hp was increased significantly 4 weeks and 3 months after medication compared with pretherapy（P〈0.05）.Conclusion Omeprazole can make the location of Hp in stomach of duodenal ulcer.