2010年我院178例药品不良反应报告分析

Report on the Analysis of 178 Cases of Adverse Drug Reaction in Our Hospital in 2010

目的:通过对我院药物应用过程中不良反应的发生情况进行分析,为临床安全合理用药提供参考。方法:将我院2010年药品ADR上报表评价审核后,采用回顾性调查的统计分析方法,对患者的一般资料、给药途径、药品类别、剂型、药品不良反应临床表现等进行统计分析。结果:178例ADR报告中,约60%通过静脉滴注给药,涉及药物以抗感染药居首位,临床表现以皮肤及其附件最多共70例(39%),发生于用药30min以内共计71例(40%),严重不良反应报告15例(8.4%)。结论:不良反应的发生与药品种类、给药途径、患者年龄等因素相关,临床应加强开展药物的不良反应监测,警示严重不良反应,科学规避用药风险,促进临床安全、合理用药。

Objective：Analyze the adverse drug reaction cases in order to provide a reference for the safe and rational use of drugs in the clinical practice.Methods：Retrospective investigation has been implemented to 178 cases of ADR in our hospital in 2010.The information on the patients＇ background,the way of obtaining the drugs,and the types of drugs,the formulations of drugs,and clinical manifestation of ADRs are analyzed using statistical methods.Results：Out of the 178 ADR cases,60% were caused by taking drug through intravenous drip.There are totally 120 type of drugs evolved in ADR cases.The most relevant drug is anti-infective,including 40% out of 120（48 cases）.The most popular clinical manifestation of ADR is on skin and its appendages,happened for 39% of 178 cases（70 cases）.Moreover,about 39.3% of all 178 ADR cases（71 cases） occurred within 30 minutes immediately after the drug uses.There are 15 ADR cases,which were very severe ones,accounting for 8.4% of all cases.Conclusion：The occurrence of ADRs are affected by many factors,including the types of drugs,the way of obtaining drugs,the patients＇ages,and so on,suggesting that a regulation system of the adverse reaction after the drug use can provide a good signal for more serious adverse events,help avoid the risk of drug use,and promote a safe use of drugs in the clinical practices.