颅内支架植入术后支架内亚急性血栓形成临床分析

Analysis of subacute thrombosis after stent implanting in intracranial artery

目的探讨颅内支架植入术后亚急性血栓形成的临床特点。方法分析2例颅内支架植入术后亚急性血栓形成的临床资料并复习相关文献。结果 2例均为大脑中动脉M1段狭窄支架植入术后,均经及时的动脉溶栓再通,溶栓后加大抗血小板药物用量、延长抗凝治疗时间未再复发。结论抗血小板、抗凝治疗不足可能是颅内支架植入术后亚急性血栓形成的重要原因,血栓形成后及时的动脉溶栓,溶栓术后强化抗血小板、抗凝治疗,可能取得良好的疗效。

Objective To explore the clinical features of subacute in-stent thrombosis after stent implanting in intracranial artery.Methods Clinical data of two cases of subacute intracranial stent thrombosis were analyzed,and the pertinent literature was reviewed.Results Two cases with stent thrombosis were subacute onset after stent implantation in M1 segment of middle cerebral artery.Blood vessels were recanalized by timely arterial thrombolysis.Thrombosis has no recurrence by increasing antiplatelet drug dosage and prolonging anticoagulant therapy after arterial thrombolysis.Conclusion The lack of antiplatelet and anticoagulant therapy may be an important factor that lead subacute in-stent thrombosis.Timely arterial thrombolysis after thrombosis and enhancing antiplatelet and anticoagulant therapy after thrombolysis may achieve good efficacy.