血浆不对称二甲基精氨酸水平与颈动脉硬化之间关系的研究

Research on the relationship between the plasma levels of asymmetric dimethylarginine and carotid atherosclerosis

目的评价血浆不对称二甲基精氨酸水平与颈动脉硬化之间的关系,进一步研究动脉硬化及缺血性脑血管病相关的危险因素。方法脑梗死患者32例,对照组为与脑血管病无关的同期住院患者30例。所有研究对象均行颈部血管彩超检查,并检测所有研究对象空腹不对称二甲基精氨酸水平。比较2组患者之间不对称二甲基精氨酸水平之间的差异。结果脑梗死患者动脉中膜厚度明显高于对照组,二者比较,差异有统计学意义(P<0.05);脑梗死患者血浆不对称二甲基精氨酸水平亦高于对照组,二者比较,差异有统计学意义(P<0.05)。血浆不对称二甲基精氨酸水平与颈动脉内膜厚度呈正相关。结论高不对称二甲基精氨酸水平可能与动脉硬化的形成有关,可能为缺血性脑血管病的危险因素。

Objective To evaluate the relationship between the plasma levels of asymmetric dimethylarginine and carotid atherosclerosis and further research the associated risk factors of ischemic cerebrovaseular disease. Methods Thirty-two patients with cerebral infarction and 30 patients without cerebrovascular disease were adopted to this research. All subjects under- went neck vascular ultrasound examination, and test of the levels of asymmetric dimethylarginine. The team of researchers also evaluated the relationship of the levels of asymmetric dimethylarginine and carotid atherosclerosis. Results The intimal media thickness of neck vascular and the plasma levels of asymmetric dimethylarginine in patients with cerebral infarction were signifi- cantly higher than non-cerebral infarction patients （P〈O. 05）. The plasma levels of asymmetric dimethylarginine were positive- ly correlated to carotid intima-media thickness. Conclusion High levels of asymmetric dimethylarginine may be associated with the formation of atherosclerosis, which may be one of risk factors of ischemic cerebrovascular disease.