血压昼夜节律与动脉硬化关系的研究

Relationship between circadian rhythms of blood pressure and arteriosclerosis

目的探讨血压昼夜节律与动脉硬化的关系。方法 218例原发性高血压患者根据动态血压监测曲线分为勺型组(n=86)、非勺型组(n=92)、反勺型(n=8)、超勺型组(n=12)四组。检测患者动脉硬化指标踝臂指数(ABI)、臂踝脉搏波传导速度(baPWV),并与勺型组患者ABI、baPWV进行对比与分析。结果非勺型组、反勺型、超勺型组患者较勺型组患者ABI呈减低趋势,而baPWV呈增加趋势,差异有显著统计学意义(P均<0.01)。结论高血压患者的血压昼夜节律与动脉硬化严重程度相关,维持血压正常昼夜节律可以减缓动脉硬化发展的进程。

Objective To investigate the relationship between circadian rhythms of blood pressure and arteriosclerosis.Methods The patients with primary hypertension（n=218） were divided into the dipper group（n=86）,non-dipper group（n=92）,reverse dipper group（n=8） and ultra-dipper group（n=12） according to the dynamic monitoring curve of blood pressure.The ankle-brachial index（ABI） and brachial-ankle pulse wave velocity（baPWV） were detected in all patients,and compared and analysed with the dipper group.Results ABI showed a decrease trend and baPWV showed a increase trend in the non-dipper group,reverse dipper group and ultra-dipper group compared with the dipper group,and the difference was statistically significant（all P0.01）.Conclusion The circadian rhythms of blood pressure is correlated to arteriosclerosis in hypertensive patients.Keeping normal circadian rhythms of blood pressure will retard the development of arteriosclerosis.