高血压前期与血尿酸、C-反应蛋白的相关性研究

Correlation among prehypertension,serum uric acid and C-reactive protein

目的探讨高血压前期与血尿酸(UA)、C-反应蛋白(CRP)水平的关系及临床意义。方法入选2010年门诊体检人群176例,按照血压水平分为血压正常组(n=56)、高血压前期组(n=66)、高血压组(n=54)三组,检测受试者血UA、CRP及总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、体质指数(BMI)、空腹血糖(FBG)水平。采用多元线性逐步回归分析UA、CRP对血压的影响。结果①三组间TC、TG、LDL-C、HDL-C、BMI及FBG、收缩压(SBP)、舒张压(DBP)水平比较,差异均有统计学意义(P均<0.01);②高血压前期组血UA、CRP水平均显著高于正常血压组(P<0.01),同时低于高血压组(P<0.01);③多元线性回归分析显示血UA、CRP分别与SBP、DBP呈独立相关(P<0.05～0.01)。结论高血压前期患者已有血UA、CRP水平的升高,血UA、CRP与血压独立相关。

Objective To study the relationship among prehypertension,serum uric acid and C-reactive protein（CRP） and clinical significance.Methods The OPD physical-exam persons（n=176） in 2010 were chosen and divided into the normal group（n=56）,prehypertension group（n=66） and hypertension group（n=54）.The levels of serum uric acid（UA）,CRP,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,body mass index（BMI） and fasting plasma glucose were detected.The influences of UA and CRP on blood pressure were analysed by using multiple linear stepwise regression.Results ①The comparison of levels of TC,TG,LDL-C,HDL-C,BMI,FBG,systolic blood pressure（SBP） and diastolic blood pressure（DBP） among three groups showed that the difference was significant statistically（all P0.01）.②The levels of serum UA and CRP were higher in the prehypertension group than those in the normal group（P0.01）,and lower than those in the hypertension group（P0.01）.③The result of multiple linear stepwise regression showed that UA and CRP were,respectively,correlated to SBP and DBP independently（P0.05~P0.01）.Conclusion The patients with prehypertension have higher levels of UA and CRP,which are correlated to blood pressure independently.