宫颈癌新辅助化疗57例疗效观察

Observation on therapeutic effect of neoadjuvant chemotherapy treatment for 57 patients with cervical cancer

目的探讨新辅助化疗（NACT）辅助治疗Ⅱa期至Ⅱb期宫颈癌的临床效果。方法将57例Ⅱa期至Ⅱb期宫颈癌患者，采用1～2个疗程的静脉化疗之后2剧全部行宫颈癌根治术，并观察患者病灶大小的改变、化疗毒副反应、术中术后并发症等在新辅助化疗在宫颈癌治疗中的效果。结果NACT有效45例（78．95％），其中9例（15．79％）完全缓解。Ⅱa期有效33例，11b期有效12例，两者相比差异无统计学意义（P〉0．05）。期别与化疗效果无关，而与病理类型有关，鳞癌的有效率90．70％明显高于腺癌42．86％（P〈0．05）。化疗毒副反应轻微。本组患者化疗后均行宫颈癌根治术。结论宫颈癌新辅助化疗可以缩减肿瘤的体积和范同、降低肿瘤的分期，提高手术切除率，是安全有效的，可改善患者生活质量，不良反应可耐受，易处理，是一种有效的治疗方法。

Objective To discuss the clinical effect of the neoadjuvant chemotherapy treatment for the Ⅱa to Ⅱb period cervical cancer.Methods Chose 57 patients with effective in the to Ⅱb period cervical cancer, were treated for one to two course of treatment vein chemotherapy,after two weeks,all had cervical cancer radical correction,and observed the patient＇ s change of the focus, toxic and side-ef- fect, complication and so on ,they were in the neoadjuvant chemotherapy of the treatment of the cervical cancer.Results 45 cases were effective in the NACT（78.95percent）,9 cases of them were all relief（ 15.79percent ）.33 cases were effective in the effective in the 1I a period, 12 cases were effective in the effective in the lIb period,there were no different statistical significance between them（P〉0.05）.There were no relation between the period and the effects of chemotherapy, relation with pathology style. The effective rate of the squamous cancer was 90.70 percent, was higher than adenocarcinoma 42.86 percent （P〈0.05）. The toxic and side-effect was light. All the patients were treated by the cervical cancer radical correction.Conclusion The neoadjuvant chemotherapy treatment for the cervical cancer can short the volume and hound of the tumour,low the period of the tumour,improve the excision rate ,it is safe and effective,can improve the patients quality life,and the untoward effect is light,it is a good way.