摘要
总结了第一代抗组胺药盐酸羟嗪及其重要中间体2-(2-氯乙氧基)乙醇和母环1-[(4-氯苯基)苯甲基]-哌嗪的各种合成路线,并对各路线进行了评述,选出了一条适合工业化的路线:由1-[(4-氯苯基)苯甲基]-哌嗪与2-(2-氯乙氧基)乙醇缩合,酸化,制得盐酸羟嗪。
Various synthetic routes of the first generation antihistamines hydroxyzme mnyarocmorme, its key intermediate 2-（2-chloroethoxy） ethanol and the main ring 1-V（4-chlorophenyl）benzyl]-piperazine were summarized and commented. A suitable route for industrialization was selected as follows.hydroxyzine dihydrochloride was obtained through condensation of 2-（2-chloroethoxy） ethanol and 1-[（4-chlorophenyl）benzyl^-pi- oerazine, acidification.
出处
《化学与生物工程》
CAS
2011年第8期1-4,共4页
Chemistry & Bioengineering
