摘要
目的研究痰热清注射液对慢性阻塞性肺疾病(COPD)急性加重期患者诱导痰免疫因子的影响。方法 56例COPD急性加重期患者随机分为痰热清治疗组和对照治疗组,分别于治疗前及治疗第1,3,5天行诱导痰炎性细胞计数、测上清液hs-CRP、IL-8、TNF-α的动态变化含量。并与28例健康人比较。结果 56例COPD急性加重期患者治疗前诱导痰中性粒细胞百分比、hs-CRP、IL-8、TNF-α水平与健康人比较均明显升高,差异均有显著性(P<0.05);痰热清治疗组在治疗后第3天诱导痰PMN%、hs-CRP、IL-8、TNF-α水平较对照治疗组开始显著下降(P<0.05);第5天诱导痰PMN%、hs-CRP、IL-8、TNF-α水平均较对照治疗组显著下降(P<0.05)。结论痰热清注射液在COPD急性加重期患者治疗中,通过抑制过度的炎症反应,可减轻COPD患者气道炎症反而发挥治疗作用。
Objective To observe the effects of Tanreqing injection on the immune factors in induced sputum from patients with acute period of COPD.Methods Totally 56 patients with acute period of COPD were randomly divided into trial group and control group.induced sputum levels of PMN %,hs-CRP,IL-8 and TNF-α were determined at 0,1,3 and 5 days after treatment.Results The induced sputum levels of PMN%,hs-CRP,IL-8 and TNF-α in all 56 COPD patients were significantly higher than normal levels;On day 3,induced sputum levels of PMN%、hs-CRP、IL-8 and TNF-α in the trial group began to decrease significantly as compared with that of the control group(P0.05);on day5,induced sputum ievels of PMN%,hs-CRP,IL-8 and TNF-α were significantly lower than that in the control group(P0.05).Conclusions As an adjunctive therapy for COPD,Tanreqing injection can suppress excessive inflammatory reaction.
出处
《医药论坛杂志》
2011年第13期6-8,共3页
Journal of Medical Forum