高血压病不同分级和不同年龄中肾素-血管紧张素Ⅱ-醛固酮活性的相关性研究

Correlation between different BP levels of essential hypertension and different age in systematic RAS

目的:探讨高血压病不同分级和不同年龄患者中血浆肾素-血管紧张素Ⅱ-醛固酮活性变化的规律。方法:原发性高血压172例,按高血压分级标准分为3组,按年龄分为4组。分别测定不同组间的血浆肾素-血管紧张素Ⅱ-醛固酮活性浓度。结果:不同分级高血压组间的血浆肾素-血管紧张素Ⅱ-醛固酮活性浓度差异无统计学意义。以55岁分界,≤54岁各年龄组和≥55岁各年龄组之间的血浆肾素-血管紧张素Ⅱ活性浓度差异有统计学意义(P<0.05),而醛固酮在各年龄组间活性无统计学差异。结论:血浆肾素-血管紧张素Ⅱ-醛固酮活性随年龄的增长而减弱,血浆肾素-血管紧张素Ⅱ活性在54岁以下的高血压病患者中明显增加。血浆肾素-血管紧张素Ⅱ-醛固酮活性在不同分级的高血压患者中无变化。

Objective：To investigate the relationship between different BP levels and ages of essential hypertension in systematic RAS.Method： A sample of 172 patients with essential hypertension were divided with different BP levels into three groups and with different ages into four groups,it was detected the activity of the reenin ANGⅡ Aldosterone in every groups.Results： The activity of rennin ANGⅡ Aldosterone in different BP levels of essential hypertension has no significant difference（P0.05）.The activity of rennin ANGⅡbetween the Age groups less than 54 years and over 55 years has significant difference（P0.05）.Conclusions： The activity of rennin ANGⅡ is significand increase at age less than 54 years.The activity of rennin ANGⅡAldosterone is no difference in all BP levels with essential hypertension.