雌孕激素受体的表达对分娩发动的影响

The Effects of distribution change of estrogen receptor and progestogen receptor on initial of parturition unit

目的:检测雌、孕激素受体在自然临产经阴道分娩以及选择性剖宫产产妇的胎盘组织中的表达,探讨雌、孕激素受体(ER,PR)的表达对分娩发动的影响及其机制。方法:运用免疫组化法检测22例自然临产经阴道分娩的产妇胎盘和胎膜中ER、PR的表达情况,以18例选择性剖宫产为对照,并结合临床资料对实验数据进行统计学分析。结果:①实验组和对照组PR阳性率分别为73.79±13.09%、74.02±14.40%,两组对照,无统计学差异(P>0.05)。②自然临产组和选择性剖宫产组胎盘组织中的ER阳性表达率分别为86.11±14.90%和82.65±14.30%,两组相比无显著性差异(P>0.05)。结论:人类妊娠末至分娩发动前,ER、PR在妊娠组织中的表达水平均无显著下降。功能性孕激素撤退可能就是分娩发动的启动因素。

Objective：To detect the expression of estrogen receptor（ER） and progesterone receptor（PR） in Placenta and fetal membranes,which comes from Natural delivery and elective caesarean section.To investigate the effection and mechanism of estrogen receptor,progesterone receptor＇ change on the onset of labor.Methods： Use immunohistochemistry method to detect the expression of estrogen and progesterone receptors ER,PR in 22 cases natural delivery,18 cases elective caesarean section as control.Result： 1,In natural dilivery group and elective cesarean section group,PR positive expression rates were 73.91±13.09% and 74.02±14.40%.There has not marked difference between them.2,In natural dilivery group and selective cesarean section group,ER positive expression rates were 86.11±14.90% and 82.65±14.30%.There has no distinctly difference between them.Conclusion： In human parturition,the level of P didn＇t decrease in circulation and uterus region,the onset of labor possible caused by some kind functional defect of P,i.e ＂ P functional withdrawal ＂.Some kind functional defect of P decreased P combined to PR,P can＇t play its funtion of maintaining uterus relaxed state,Uterine sensibility and responsivity to stimulating factor increased.