恶性肿瘤住院患者合并铜绿假单胞菌感染及耐药性分析

Analysis of the Pseudomonas aeruginosa infection and antibiotic resistance in patients with malignant tumor

目的:探讨我院恶性肿瘤住院患者合并铜绿假单胞菌(PAE)感染的耐药情况,为临床合理用药提供科学依据。方法:细菌鉴定采用手工法和美国MicroScan WalkAway40SI全自动微生物分析仪进行。药敏试验采用K-B纸片扩散法,用WHONET5.4软件进行统计分析。结果:本研究共检出G-杆菌2889株,其中PAE 254株(8.8%);PAE感染有逐年上升趋势(P<0.05)。PAE感染主要集中于内科、放疗和ICU等科室;PAE对环丙沙星的耐药率最低(8.3%)、其次为头孢哌酮/舒巴坦(10.2%)、头孢他啶(11.0%)、阿米卡星(11.4%)、美洛培南(11.8%)、哌拉西林/他唑巴坦(13.4%)、亚胺培南(14.2%)、头孢吡肟(14.2%)、左氧氟沙星(14.6%)等,而对复方新诺明的耐药率最高(95.3%)。结论:PAE是我院恶性肿瘤住院患者合并感染的主要病原菌之一,对多种抗菌药物均产生不同程度的耐药性。

Objective：To provide scientific basis for clinical rational drug use in our hospital through exploration on drug resistance of inpatients with malignant tumors complicated with pseudomonas aeruginosa infection.Methods：Identification of bacteria was realized by using manual method and the U.S.MicroScan WalkAway40SI automatic microorganism analyzer.Drug sensitivity test was done by K-B disk diffusion method with WHONET5.4 software for statistical analysis.Results：2889 strains were detected with G-bacillus,including PAE strain 254（8.8%）;PAE infection is increasing year by year（P0.05）.The PAE infection mainly focus on internal medicine wards and ICU departments in radiotherapy ward;PAE on ciprofloxacin resistance rate was the lowest（8.3%）,followed by cefoperazone/shu ba stein（10.2%）,ceftazidime（11%）,amikacin（11.4%）,meropenem（11.8%） and piperacillin/he zuo batan（13.4%）,imipenem（14.2%）,cefepime（14.2%）,levofloxacin（14.6%）,and resistance rate to cotrimoxazole was the highest（95.3%）.Conclusion：PAE is one of the main pathogens in inpatients with malignant tumors complicated with infection in our hospital,which has varying degrees of resistance to different kinds of antimicrobial agents.