肥胖儿童血清瘦素水平分析

Analysis of leptin level in serum of obese children

目的:检测肥胖儿童和正常对照儿童血清瘦素水平,探讨瘦素与体重指数、空腹血糖、胰岛素、胰岛素抵抗指数及血脂等的相关性。方法:对100例肥胖儿童及100例正常对照儿童测量身高、体重,计算体重指数(BMI);检测空腹血糖(FPG)、胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB);胰岛素抵抗采用稳态模式评估法的胰岛素抵抗指数(HOMA-IR)指标;血清瘦素采用酶联免疫吸附试验检测。结果:肥胖儿童组血清瘦素显著高于正常对照组儿童(P<0.05);血清瘦素与BMI、ALT、TG、LDL-C、APB、FINS、HOMA呈正相关r,值分别为(0.647,0.5840,.328,0.198,0.314,0.5230,.484,P值均<0.05);与HDL-C呈负相关(r=-0.151,P<0.05)。结论:瘦素作为一种脂肪因子,在儿童肥胖的发生中起重要作用。

Objective：To assay the serum leptin levels in normal control children and obese children,to explore the correlation between leptin and body mass index,fasting plasma glucose,insulin,insulin resistance index,lipids etc.Methods：Of 100 cases of obese children and 100 normal control children,measured height,weight,calculated body mass index（BMI）;detected fasting plasma glucose（FPG）,insulin（FINS）,total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A（ApoA）,apolipoprotein B（ApoB）;insulin resistance using homeostasis model assessment insulin resistance index（HOMA-IR）;serum leptin was measured by ELISA.Results：The obese children had significantly higher levels of leptin compared with normal control children,P0.05.Serum leptin levels correlated positively with BMI,TG,LDL-C,APB,FINS,HOMA and negatively with HDL-C,P0.05.Conclusion：As a fat factor,leptin plays an important role in the incidence of children obesity.