门诊老年心血管病患者口服药联用分析

Analysis of the Combined Use of Oral Drugs in Elderly Outpatients with Cardiovascular Disease

目的:采用回顾性调查方式了解我院心血管病老年患者口服药物联合使用情况,并分析其相互作用及可能导致的不良反应。方法:抽取2010年我院门诊老年心血管疾病患者(>60岁)处方(包含慢性病处方)5000张进行分析,统计患者基本情况及口服药应用种类,分析处方中存在的药物相互作用及可能导致的不良反应。结果:超过30%的老年心血管病患者同时口服5种或以上药物,775张处方有潜在的药物相互作用。结论:该院门诊为老年心血管疾病患者开具的存在药物相互作用的处方多为同时患有多种疾病的患者,其口服药种类过多可致患者产生不良反应的机率大大增加,部份处方存在可导致患者产生严重不良反应的药物联合应用,应加强对处方的审查和评价。

Objective：Using the retrospective survey method to investigate the combined use of oral drugs in elderly outpatients with cardiovascular disease of our hospital in 2010,and analyze the interactions and adverse reactions which might happen.Method： 5 000 prescriptions of elderly patients with cardiovascular disease in our hospital（〉60 years）（including the chronic disease prescriptions） were enrolled and the basic information of these elderly outpatients,the types of prescription medications,the interactions and adverse reactions which might happen were analyzed.Result：Above 30%of the elderly patients with cardiovascular disease took more than 5 oral medications,and 775 prescriptions were with potential drug interactions.Conclusion：The prescriptions with drug interactions often happened in the elderly outpatients suffering from various diseases.Too many types of oral medications may greatly increase the probability of excessive adverse reactions,especially combined use in some prescriptions may lead to serious adverse reactions.