摘要
代替的 nitroacetates 和 N-Boc imines 的不对称的 aza-Henry 反应与新型的 thiourea-guanidine bifunctional organocatalyst 被完成。新奇转变展出了忍受邻近的第四级、第三级的 chiral 中心的高 diastereoselectivities,和 adducts 通常被获得在对好 enantioselectivities (多达 88% ee ) 中等。
The asymmetric aza-Henry reaction of α-substituted nitroacetates and N-Boc imines was achieved with a new-type thioureaguanidine bifunctional organocatalyst.The novel transformations exhibited high diastereoselectivities,and the adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in moderate to good enantioselectivities(up to 88%ee).
基金
the Scientific Research Fund ofSichuan Provincial Education Department(No.310-347)
Technology Department of Chengdu University of TCM(Nos.310-446 and 310-448)for financial support