Asymmetric aza-Henry reaction with α-substituted nitroacetates catalyzed by a bifunctional thiourea-guanidine catalyst

代替的 nitroacetates 和 N-Boc imines 的不对称的 aza-Henry 反应与新型的 thiourea-guanidine bifunctional organocatalyst 被完成。新奇转变展出了忍受邻近的第四级、第三级的 chiral 中心的高 diastereoselectivities，和 adducts 通常被获得在对好 enantioselectivities (多达 88% ee ) 中等。

The asymmetric aza-Henry reaction of α-substituted nitroacetates and N-Boc imines was achieved with a new-type thioureaguanidine bifunctional organocatalyst.The novel transformations exhibited high diastereoselectivities,and the adducts bearing adjacent quaternary and tertiary chiral centers were generally obtained in moderate to good enantioselectivities（up to 88%ee）.