不同程度冠状动脉病变患者的血管性假血友病因子检测

The level of plasma von Willebrand factor in patients with different degrees of coronary artery lesions

目的探讨不同程度冠脉病变患者的血管性假血友病因子（von Willebrand factor，vwF）水平。方法检测111例冠心病（CHD）及25例非CHD患者的血浆vWF水平。对所有人选患者行冠脉造影检查，将CHD患者根据冠状动脉病变支数分为单支、双支和多支病变组；根据冠状动脉损伤形态分为A型低危病变组、B型中危病变组和C型高危病变组；分析血浆vWF水平与冠状动脉病变的范围及程度的关系。结果CHD多支病变组的血浆vWF水平较单支病变组、双支病变组明显升高[（197．42±6．57）％比（135．24±21．56）％、（170．94±15．75）％，P〈0．01、P〈0．05]；双支病变组的血浆vWF水平较单支病变组也明显升高（P〈0．05）；对照组与单支病变组的血浆vWF水平差异无统计学意义。C型病变组vwF高于A型、B型病变组[（195．25±33．71）％比（132．10±28．26）％、（161．13±37．41）％，19〈0．01]，B型病变组高于A型病变组（P〈0．01）。结论血浆vwF水平能反映冠脉病变的范围及程度。

Objective To detect the plasma levels of von Willebrand factor （vWF） in patients with dif- ferent degrees of coronary artery lesions. Methods 111 patients with CHD were enrolled in this study, 25 patients without CHD as control group. Plasma levels of vWF were detected for all patients before coronary arteriog- raphy. The correlations of the number of impaired coronary arteries （CA）, the level of coronary stenosis with levels of vWF were compared. Results The level of vWF was significantly higher in patients who had complex lesions compared with those who had simple or no lesions （P〈0.05 or P〈0.01 ）. Conclusion Plasma levels of vWF are significantly associated with more complex lesions.