非霍奇金淋巴瘤细胞病理学形态特征和免疫表型分析

Cytopathological characteristics and immunophenotype analysis of Non Hodgkin's lymphoma

目的:探讨非霍奇金淋巴瘤(NHL)诊断特点,结合细胞免疫化学做出明确诊断。方法:选择本室2000年1月-2008年4月经临床追踪及病理学证实的NHL165例,由有经验的医生进行复阅。结果:165例病例中,男90例,女75例;年龄最大者98岁,最小者1岁,平均年龄40.7岁;部位以颈部淋巴结为首位共81例,其次是锁骨上及腹股沟,分别为25及16例,胸腹水13例,睾丸3例,乳腺4例,其他部位12例。经组织学对照,假阴性9例,占5.45%,准确率94.55%,假阳性2例,占1.21%。结论:正确掌握NHL细胞病理学特点,结合免疫组织化学,绝大多数NHL可以通过FNA做出正确诊断。

Objective： To analyze the cytopathological characteristics and immunophenotype of Non Hodgkin＇s lymphoma （NHL） by needle biopsy. Method：Rediagnosis of 165 NHL needle biopsy samples which were collected from January 2000 to April 2008 and confirmed by pathological and immunopathological diagnosis in the Unit of Cytopathology of Tongji Hospital. Result： The 165 cases diagnosed with NHL included 90 males and 75 females, and the average age was 40.7, from 1 to 98 years old. Among the 165 NHL samples, 81 were from cervical lymph node, 25 from supraclavicular lymph node and 16 from inguinal lymph node, and among others, 13 from hydrothorax or/and ascites, 3 from testiculus,4 from breast,and 12 other sites. Compared with the pathological diagnosis, the coincidence rate of cytopathology was 94.55%, while the false negative and positive rate was 5.45% and 1.21%, respectively. Conclusion： Most of NHL could be diagnosed correctly with needle biopsy by the cytomorphological characteristics, with the help of immunophentype analysis.